Journal of Medical Physics
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Year : 2022  |  Volume : 47  |  Issue : 4  |  Page : 381-386

Photon interaction coefficients for the colorectal cancer tissue

1 Department of Radiography and Radiological Sciences, Faculty of Allied Medical Sciences, University of Calabar, Calabar, Nigeria
2 Department of Physics, Faculty of Physical Sciences, University of Calabar, Calabar, Nigeria
3 Department of Pathology, University of Calabar, Calabar, Nigeria

Correspondence Address:
Dr. Emmanuel Okon Esien-Umo
Department of Radiography and Radiological Science, Faculty of Allied Medical Sciences, University of Calabar, Calabar
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmp.jmp_29_22

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Purpose: The application of radiotherapy to the treatment of cancer requires the knowledge of photon interaction coefficients such as mass attenuation (μm) and mass energy-absorption coefficients (μen/ρ). Although these coefficients have been determined for different tissues, it is lacking for the colorectal cancer (CRC) tissue in the literature. This study determines the μm and μen/ρ for the CRC tissue within the radiotherapy energy range. Materials and Methods: The CRC tissue from autopsy patients was freeze-dried, grounded into a fine powder, and made into pellets of 1 cm thickness. The elements detected in the CRC tissue using Rutherford backscattering spectrometry were used in XCOM to determine the theoretical values of μm and μen/ρ. The CRC tissue was again exposed to X-rays of energies of 6 and 15MV, respectively, to determine its experimental values of μm and μen/ρ. Results: Elements detected included carbon, oxygen and nitrogen making up 96.67%, high atomic number and trace elements making up the remaining 3.33% fraction of the CRC tissue. Conclusion: The theoretical and experimental μm and μen/ρ values showed a good agreement of about 2% difference between them. These values can be used to simulate the CRC tissue with respect to μm and μen/ρ.

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