Journal of Medical Physics
 Home | Search | Ahead of print | Current Issue | Archives | Instructions | Subscription | Login  The official journal of AMPI, IOMP and AFOMP      
 Users online: 134  Home  EMail this page Print this page Decrease font size Default font size Increase font size 
Year : 2022  |  Volume : 47  |  Issue : 4  |  Page : 344-351

Comparison of three commercial methods of cone-beam computed tomography-based dosimetric analysis of head-and-neck patients with weight loss

Department of Oncology, University of Alberta; Department of Medical Physics, Cross Cancer Institute, Edmonton, Alberta, Canada

Correspondence Address:
Dr. Satyapal Rathee
Department of Oncology, University of Alberta and Department of Medical Physics, Cross Cancer Institute, 11560 University Ave, Edmonton, Alberta T6G 1Z2
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmp.jmp_7_22

Rights and Permissions

Purpose: This investigation compares three commercial methods of cone-beam computed tomography (CBCT)-based dosimetric analysis to a method based on repeat computed tomography (CT). Materials and Methods: Seventeen head-and-neck patients treated in 2020, and with a repeat CT, were included in the analyses. The planning CT was deformed to anatomy in repeat CT to generate a reference plan. Two of the CBCT-based methods generated test plans by deforming the planning CT to CBCT of fraction N using VelocityAI™ and SmartAdapt®. The third method compared directly calculated doses on the CBCT for fraction 1 and fraction N, using PerFraction™. Maximum dose to spinal cord (Cord_dmax) and dose to 95% volume (D95) of planning target volumes (PTVs) were used to assess “need to replan” criteria. Results: The VelocityAI™ method provided results that most accurately matched the reference plan in “need to replan” criteria using either Cord_dmax or PTV D95. SmartAdapt® method overestimated the change in Cord_dmax (6.77% vs. 3.85%, P < 0.01) and change in cord volume (9.56% vs. 0.67%, P < 0.01) resulting in increased false positives in “need to replan” criteria, and performed similarly to VelocityAI™ for D95, but yielded more false negatives. PerFraction™ method underestimated Cord_dmax, did not perform any volume deformation, and missed all “need to replan” cases based on cord dose. It also yielded high false negatives using the D95 PTV criteria. Conclusions: The VelocityAI™-based method using fraction N CBCT is most similar to the reference plan using repeat CT; the other two methods had significant differences.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded40    
    Comments [Add]    

Recommend this journal