Journal of Medical Physics
 Home | Search | Ahead of print | Current Issue | Archives | Instructions | Subscription | Login  The official journal of AMPI, IOMP and AFOMP      
 Users online: 518  Home  EMail this page Print this page Decrease font size Default font size Increase font size 
Year : 2021  |  Volume : 46  |  Issue : 3  |  Page : 154-161

Synthesis, characterization, and cytotoxicity evaluation of polyethylene glycol-coated iron oxide nanoparticles for radiotherapy application

1 Department of Medical Physics, Center for Interdisciplinary Research, D.Y. Patil Education Society(Deemed to be University), Kolhapur, Maharashtra, India
2 Department of Radiotherapy, Integrated Cancer Treatment and Research Centre, Pune, Maharashtra, India
3 Department of Physics, Savitri Bai Phule Pune University, Pune, Maharashtra, India

Correspondence Address:
Dr. Padmaja N Pawaskar
Department of Medical Physics, Center for Interdisciplinary Research, D.Y. Patil Education Society(Deemed to be University), Kolhapur-416006, Maharashtra
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmp.JMP_102_20

Rights and Permissions

Background: Treatment methods for cancer that are widely being utilized affect both normal and cancerous cells. We report synthesis polyethylene glycol (PEG)-coated Fe3O4 nanoparticles (NPs) and its characteristic properties and appraise its potential as a promising radiation sensitizer candidate in radiotherapy that improves cancer treatment and reduces side effects of radiation. Materials and methods: PEG-coated Fe3O4 NPs were synthesized by chemical coprecipitation method and characterized by studying their size, structure, functional group, stability, magnetization, and cytotoxicity using different techniques. X-ray powder diffraction, Fourier transform infrared spectroscopy, and thermogravimetric analysis results show that Fe3O4 NPs have been functionalized with PEG molecules during the course of synthesis. Results Synthesized NPs have good stability based on zeta-potential study. Dynamic light-scattering results reveal that PEG-coated Fe3O4 has a greater hydrodynamic size than bare Fe3O4. Transmission electron microscopy (TEM) micrograph exhibited that NPs are roughly spherical with size in range of 10–20 nm. Saturation magnetization value of PEG-coated and bare Fe3O4 also confirms coating and shows superparamagnetic behavior. Cytotoxicity evaluation study indicated that PEG-coated Fe3O4 is biocompatible on L929 and toxic on Michigan Cancer Foundation-7 (MCF-7) (breast cancer cells). Conclusion: These characterized properties of PEG-coated Fe3O4 NPs show that it could be used as a potential radiosensitizer candidate in radiotherapy to significantly improve cancer treatment and minimize painful side effects of radiation.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded107    
    Comments [Add]    

Recommend this journal