Journal of Medical Physics
 Home | Search | Ahead of print | Current Issue | Archives | Instructions | Subscription | Login  The official journal of AMPI, IOMP and AFOMP      
 Users online: 1328  Home  EMail this page Print this page Decrease font size Default font size Increase font size 
Year : 2018  |  Volume : 43  |  Issue : 1  |  Page : 9-15

A treatment planning method for better management of radiation-induced oral mucositis in locally advanced head and neck cancer

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA

Correspondence Address:
Dr. Hao Howard Zhang
22 S Greene St., Baltimore, MD 21201
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmp.JMP_78_17

Rights and Permissions

Purpose/Aim: To describe a two-phase intensity-modulated radiation therapy (IMRT) treatment planning approach, that is, promising for reduction of oral mucositis risk in locally advanced head-and-neck cancer. Materials and Methods: Ten locally advanced head-and-neck cancer patients who underwent RT were retrospectively collected. Conventional IMRT and volumetric-modulated arc therapy (VMAT) plans were generated for these patients following clinical protocol. Following the first phase of generating conventional IMRT plans, our approach utilized data from Monte Carlo-based kernel superposition dose calculations corresponding to beam apertures (generated from the conventional IMRT plans) and used an exact mathematical programming-based optimization approach applying linear programming (LP) to dose optimization in the second phase. Results: Compared with conventional IMRT and VMAT treatment plans, our novel method achieved better preservation of oral cavity (16%–29% lower mean dose, P < 0.01), parotid glands (6%–17% lower mean dose, P < 0.04), and spinal cord (3-11 Gy lower maximum dose, P < 0.03) and lower doses to nonorgan-at-risk/nontarget normal tissues, with the same or better target coverage. Conclusions: Our LP-based method can be practically implemented in routine clinical use with a goal of limiting radiation-induced oral mucositis for head-and-neck cancer patients.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded224    
    Comments [Add]    

Recommend this journal