| ORIGINAL ARTICLE |
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| Year : 2011 | Volume
: 36
| Issue : 4 | Page : 220-229 |
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Dose volume histogram analysis and comparison of different radiobiological models using in-house developed software
Arun S Oinam1, Lakhwant Singh2, Arvind Shukla1, Sushmita Ghoshal1, Rakesh Kapoor1, Suresh C Sharma1
1 Department of Radiotherapy, PGIMER, Chandigarh, India
2 Department of Physics, Guru Nanak Dev University, Amritsar, Punjab, India
Correspondence Address:
Arun S Oinam
Department of Radiotherapy, Post Graduate Institute and Medical Education and Research, Chandigarh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0971-6203.89971
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The purpose of this study is to compare Lyman-Kutcher-Burman (LKB) model versus Niemierko model for normal tissue complication probability (NTCP) calculation and Niemierko model versus Poisson-based model for tumor control probability (TCP) calculation in the ranking of different treatment plans for a patient undergoing radiotherapy. The standard normal tissue tolerance data were used to test the NTCP models. LKB model can reproduce the same complication probability data of normal tissue response on radiation, whereas Niemierko model cannot reproduce the same complication probability. Both Poisson-based and Niemierko models equally reproduce the same standard TCP data in testing of TCP. In case of clinical data generated from treatment planning system, NTCP calculated using LKB model was found to be different from that calculated using Niemierko model. When the fractionation effect was considered in LKB model, the calculated values of NTCPs were different but comparable with those of Niemierko model. In case of TCP calculation using these models, Poisson-based model calculated marginally higher control probability as compared to Niemierko model. |
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